sk Skill · K-Dense-AI
oligonucleotides
Design small interfering RNA and antisense oligonucleotide sequences against a transcript, and screen them for the failure modes specific to nucleic-acid drugs. Use this skill to tile a target transcript, apply positional and thermodynamic selection rules including duplex asymmetry and nearest-neighbour melting temperature, scan candidates for seed-region complementarity to off-target transcripts, and lay out a…
Open on skills.sh ↗read 2026-09-17
- installs 8w
- 0
- 30-day movement
- starts with the next reading
- Related entries
- 1
- Connections
- 1
bashPython
- Host repository
- K-Dense-AI/drug-discovery-agent-skills
- Version
- 1.0
- Allowed tools
- Read Write Edit Bash
- Compatible with
- Requires Python 3.10+ only. Sequence tiling, nearest-neighbour thermodynamics, and seed-match scanning are implemented in the standard library, no reference sequence is bundled.
- Licence
- MIT
- Host stars
- 30
- Host language
- Python