rfdiffusion

Generate de novo protein backbones with RFdiffusion for protein-target binders, hotspot-conditioned interfaces, motif scaffolding, partial diffusion, or symmetric assemblies. Use this skill when a design workflow needs reproducible RFdiffusion contigs, residue mappings, checkpoints, seeds, batch execution, and handoff to ProteinMPNN plus independent structure validation. RFdiffusion generates backbones; it does not…