BigHugger
sk Skill · K-Dense-AI

degraders

Work on bifunctional degraders and molecular glues, where potency comes from a ternary complex rather than occupancy. Use this skill to apply the property rules that govern this beyond-rule-of-five space, reason about linker length, attachment vector and E3 ligase choice, prepare inputs for ternary complex structure prediction, and interpret degradation readouts — DC50, Dmax, cooperativity, and the hook effect that…

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bashPython
Host repository
K-Dense-AI/drug-discovery-agent-skills
Version
1.0
Allowed tools
Read Write Edit Bash
Compatible with
Requires Python 3.10+. The bundled scripts implement degrader property rules, linker metrics, AlphaFold3, or DeepTernary) with its own licence and, in most cases, a GPU.
Licence
MIT
Host stars
30
Host language
Python